Researchers at John Hopkins have evidence that curbed activity from several key chemicals on the inner lining of the nose is linked to chronic sinusitis. Some chemicals fails to respond to current treatments. According to U.S. Centers for Disease Control and Prevention, persistent inflammation of the moist tissue that lines the nose and sinus cavities results in clogged passages and recurring infections. The team of scientists found that the activity of at least 4 genes were seriously decreased in chronic sufferers of sinusitis during the treatment. It is also found that the production of 2 proteins critical to this defence was 20 to 200 times less than normal.
Sinuses are cavities in the frontal bones, the sphenoid bones, the maxillary bone, and the mastoid processes of the temporal bone that are lined with mucous membrane and that open into the nasal cavity. Sinuses are often infected by bacteria, causing inflammation and producing severe pain. Acute sinusitis is treated with antibiotics; chronic sinusitis is extremely difficult to eradicate.
Johns Hopkins University is an institution of higher learning, in Baltimore, Maryland. The university was founded in 1876. Funds for its establishment were provided in a bequest of $3.5 million by the American financier Johns Hopkins. He left an equal amount to found the Johns Hopkins Hospital, opened in 1893, which trains students of the university medical school.
Centers for Disease Control and Prevention (CDC), agency of the United States Public Health Service, with headquarters and main laboratories in Atlanta, Georgia. The CDC conducts research into the origin and occurrence of diseases and develops methods for their control and prevention. It also develops immunization services, together with state and local agencies; provides public health information; and aids in the training of health workers. It has nine major operating divisions, including the Center for Environmental Health and Injury Control and the Epidemiology Program Office. The CDC conducts international programs as well.